Polymeric drug delivery capabilities offer several advantages over conventional oral or parenteral dosage forms. First, implantable devices allow site specific drug administration where the drug is most needed. This may also allow for significantly lower doses of drug which can minimize potential side effects. Second, implantable devices allow for sustained release of a therapeutic agent, as highlighted in the illustration below. Clearance of the drug after an injection may result in significant time outside of the therapeutic window. The last and perhaps most important advantage is patient compliance, as the treatment regimen associated with an implantable device is generally less burdensome than pills or injections.
Idealized comparison of tissue drug levels for injections compared with an implantable drug delivery device. Clearance of the drug after an injection may result in significant time outside of the therapeutic window.