Intratumoral therapy injects drugs directly into tumors, offering a promising approach to fight cancer. However, traditional methods have limitations including uneven drug distribution and off-target effects. Novel dosage forms are emerging to tackle these challenges include:
- Nanoparticles: These microscopic carriers encapsulate drugs, allowing for targeted delivery to cancer cells and reduced side effects on healthy tissue.
- Hydrogels: Injectable solutions transform into gels within the tumor, creating a sustained-release depot for the drug, maximizing intratumoral concentration.
- Implants: Biodegradable implants loaded with drugs can be placed directly in the tumor, offering continuous drug release over an extended period.
These advancements hold promise for more effective and personalized cancer treatment, with researchers focusing on optimizing drug delivery, maximizing tumor cell kill, and minimizing systemic exposure.